Hyperbaric Therapy for Diabetes

Hyperbaric oxygen therapy (HBOT) has been explored as a potential adjunctive treatment for diabetic patients, particularly those with chronic wounds and foot ulcers. While the evidence is not yet conclusive, here are some key findings:

Efficacy: A 2021 systematic review and meta-analysis of controlled clinical trials found that HBOT was significantly effective in promoting complete healing of diabetic foot ulcers (OR = 0.29; 95% CI 0.14–0.61) and reducing major amputations (RR = 0.60; 95% CI 0.39–0.92). However, the evidence was less convincing for minor amputations (RR = 0.82; 95% CI 0.34–1.97).

Mechanisms: HBOT may improve insulin sensitivity by promoting glucose transporter type 4 (GLUT4) expression in muscle and stimulating uncoupling protein 1 (UCP1) in brown adipose tissue. Additionally, HBOT may enhance glucose and lipid metabolism in skeletal muscle, delaying the onset of type 2 diabetes and obesity.

Clinical applications: HBOT has been used to treat diabetic foot wounds, with reported benefits including:

Improved wound healing rates
Reduced wound size and depth
Decreased risk of amputation
Enhanced tissue oxygenation and perfusion

Role of Hyperbaric Oxygen Therapy on Microvascular Diabetic Complications and Metabolic Profile among Patients with Type 2 Diabetes Mellitus

Hyperbaric Oxygen Ameliorates Insulin Sensitivity by Increasing GLUT4 Expression in Skeletal Muscle and Stimulating UCP1 in Brown Adipose Tissue in T2DM Mice

Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus

How a blast of pure oxygen is helping diabetic patients heal

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